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Thermo Fisher Applied Biosystems Genetic Analyzers

View CSAF Summary Successful exploitation of this vulnerability could allow an attacker to modify .fsa/.hid output files, tampering with DNA data and resulting in inaccurate test results. The following versions of Thermo Fisher Applied…

IT Security Nachrichten cisa.gov 04.08.2026, 14:00 Uhr 5 Min. Lesezeit CWE-353 KRITIS / Energie Gesundheitswesen Gov & Defense Cloud & IT-Enterprise

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Summary

Successful exploitation of this vulnerability could allow an attacker to modify .fsa/.hid output files, tampering with DNA data and resulting in inaccurate test results.

The following versions of Thermo Fisher Applied Biosystems Genetic Analyzers are affected:

Applied Biosystems 3500/3500xL Series Data Collection Software <=4.0.2

Applied Biosystems 3730/3730xL Series Data Collection Software <=5.0.2

Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software <=1.2.5

Applied Biosystems SeqStudio Flex Series Instrument Software <=1.2.0

Applied Biosystems GeneMapper ID-X Software <=v1.7.3

Applied Biosystems 3130 Series Data Collection Software <=4.1

ABI PRISM 3100/3100-Avant Data Collection Software <=2.0

ABI PRISM 310 Data Collection Software <=3.1

CVSS	Vendor	Equipment	Vulnerabilities
v3 8.4	Thermo Fisher	Thermo Fisher Applied Biosystems Genetic Analyzers	Missing Support for Integrity Check

Background

Critical Infrastructure Sectors: Healthcare and Public Health

Countries/Areas Deployed: Worldwide

Company Headquarters Location: United States

Vulnerabilities

Expand All +

CVE-2026-17583

The affected product is vulnerable because its .fsa/.hid output files can be edited. An attacker could tamper with these files, altering DNA data and resulting in inaccurate DNA test outcomes.

View CVE Details

Affected Products

Thermo Fisher Applied Biosystems Genetic Analyzers

Vendor:
Thermo Fisher

Product Version:
Thermo Fisher Applied Biosystems 3500/3500xL Series Data Collection Software: <=4.0.2, Thermo Fisher Applied Biosystems 3730/3730xL Series Data Collection Software: <=5.0.2, Thermo Fisher Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software: <=1.2.5, Thermo Fisher Applied Biosystems SeqStudio Flex Series Instrument Software: <=1.2.0, Thermo Fisher Applied Biosystems GeneMapper ID-X Software: <=v1.7.3, Thermo Fisher Applied Biosystems 3130 Series Data Collection Software: <=4.1, Thermo Fisher ABI PRISM 3100/3100-Avant Data Collection Software: <=2.0, Thermo Fisher ABI PRISM 310 Data Collection Software: <=3.1

Product Status:
known_affected

Remediations

Mitigation
Thermo Fisher has developed security updates to address the vulnerability. The security updates implement the use of digital signatures on the instrument software that adds an extralayer of protection. Moving forward, this will help users verify that data files have not been modified.

Vendor fix
Applied Biosystems 3500/3500xL Series Data Collection Software: Update to version 4.0.3
https://downloads.thermofisher.com/3500_DCS_v4.0.3_Patch/v4.0.3_Patch_Installer.exe

Vendor fix
Applied Biosystems 3730/3730xL Series Data Collection Software: Update to version 5.0.3
https://downloads.thermofisher.com/3730xl_UDC_v5.0.3_Patch/3730xl_UDC_v5.0.3_Patch.exe

Vendor fix
Applied Biosystems SeqStudio Genetic Analyzer Data Collection Software: Update to version 1.2.6
https://downloads.thermofisher.com/SeqStudio/1.2.6/SeqStudio-1.2.6.abpkg

Vendor fix
Applied Biosystems SeqStudio Flex Series Instrument Software: Update to version 1.2.1
https://downloads.thermofisher.com/SeqStudioFlex/1.2.1/SeqStudioFlex-1.2.1.abpkg

Vendor fix
Applied Biosystems GeneMapper ID-X Software: Update to version 1.7.4
https://downloads.thermofisher.com/GeneMapperID-Xv1.7.4_Patch/GMIDX_v1.7.4_Patch.exe

Vendor fix
Applied Biosystems 3130 Series Data Collection Software: Product is End of Life (EoL), no update provided

Vendor fix
ABI PRISM 3100/3100-Avant Data Collection Software: Product is End of Life (EoL), no update provided

Vendor fix
ABI PRISM 310 Data Collection Software: Product is End of Life (EoL), no update provided

Mitigation
For users who are unable to immediately implement all applicable security updates, Thermo Fisher Scientific recommends implementing the following interim mitigation measures until the applicable updates have been installed:

-Maintain a secure chain of custody for files generated by the HID instrumentation throughout the analysis workflow.
-Store generated files on encrypted, password-protected storage media (for example, encrypted USB drives or encrypted hard drives).
-Restrict access to generated files to authorized personnel in accordance with your laboratory's access control policies.
-Apply the principle of least privilege by limiting user permissions on systems operating the HID instrumentation or hosting associated data analysis and secondary analysis software.
-Leverage firewall rules and network access control lists (NACLs) to restrict internet connectivity to only trusted sources.

Mitigation
For more information, refer to Thermo Fisher's security bulletin.
https://documents.thermofisher.com/TFS-Assets/CORP/Product-Guides/fsa_hid_bulletin.pdf

Relevant CWE: CWE-353 Missing Support for Integrity Check

Metrics

CVSS Version	Base Score	Base Severity	Vector String
3.1	8.4	HIGH	CVSS:3.1/AV:L/AC:L/PR:N/UI:N/S:U/C:H/I:H/A:H
4.0	8.2	HIGH	CVSS:4.0/AV:L/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:N/SC:N/SI:H/SA:N

Acknowledgments

Nathaniel Adams, Laura Gaydosh-Combs, and Kevin Dyer reported this vulnerability to CISA

Legal Notice and Terms of Use

This product is provided subject to this Notification (https://www.cisa.gov/notification) and this Privacy & Use policy (https://www.cisa.gov/privacy-policy).

Recommended Practices

CISA recommends users take defensive measures to minimize the risk of exploitation of this vulnerability.

Minimize network exposure for all control system devices and/or systems, ensuring they are not accessible from the internet.

When remote access is required, use more secure methods, such as Virtual Private Networks (VPNs), recognizing VPNs may have vulnerabilities and should be updated to the most current version available. Also recognize VPN is only as secure as the connected devices.

CISA reminds organizations to perform proper impact analysis and risk assessment prior to deploying defensive measures.

CISA also provides a section for control systems security recommended practices on the ICS webpage on cisa.gov/ics. Several CISA products detailing cyber defense best practices are available for reading and download, including Improving Industrial Control Systems Cybersecurity with Defense-in-Depth Strategies.

CISA encourages organizations to implement recommended cybersecurity strategies for proactive defense of ICS assets.

Additional mitigation guidance and recommended practices are publicly available on the ICS webpage at cisa.gov/ics in the technical information paper, ICS-TIP-12-146-01B--Targeted Cyber Intrusion Detection and Mitigation Strategies.

Organizations observing suspected malicious activity should follow established internal procedures and report findings to CISA for tracking and correlation against other incidents.

No known public exploitation specifically targeting this vulnerability has been reported to CISA at this time. This vulnerability is not exploitable remotely.

Revision History

Initial Release Date: 2026-08-04

Date	Revision	Summary
2026-08-04	1	Initial Publication

Legal Notice and Terms of Use

IoC Intelligence (1 Indikatoren)

CVE-2026-17583

CTI Threat Relationship Graph2 Knoten / 1 Relationen

CVE / Incident Software MITRE ATT&CK CWE Weakness IoC

IR-PLAYBOOK-RCEHIGH

Schritte anzeigen

SOC Incident Playbook: Remote Code Execution (RCE) Defense

WAF MitigationSofort

Virtuelles Patchen am Reverse Proxy / WAF für gefährdete URL-Pfade und Payloads aktivieren.

SecRule REQUEST_URI "@rx ..." "id:1001,phase:1,deny,status:403"

Web Shell ScanSofort

Web-Root auf neu angelegte Scripts, anomal modifizierte Dateien und Persistence scannen.

find /var/www -type f -name "*.php" -mmin -120

Outbound FilteringSofort

Ausgehenden Datenverkehr (Reverse Shells zu unbekannten IPs/Ports) blockieren.

ss -tunp | grep -E ":(4444|1337|8080|9001)"

Vendor Patching

Hersteller-Update in Staging validieren und schnellstmöglich in Produktion ausrollen.

apt update && apt --only-upgrade install <pkg>

1-Click Detection Engineering: Sigma & YARA RulesSOC Ready

Regeln anzeigen

title: Detect Exploitation - Thermo Fisher Applied Biosystems Genetic Analyzers
id: 8867054a-66d7-4269-b05d-4ab6f9783c87
status: experimental
description: Automatisch generierte SIEM-Erkennungsregel basierend auf CTI Intelligence
references:
  - https://tsecurity.de/
author: iShareStuff CTI Automated Detection Engine
date: 2026-09-24
logsource:
  category: network_connection
  product: any
detection:
  selection:
      CommandLine|contains:
        - 'exploit'
  condition: selection
falsepositives:
  - Legitime administrative Zugriffe oder Penetrationstests
level: high
tags:
  - attack.initial_access

rule CTI_Threat_Indicator {
    meta:
        author = "iShareStuff CTI Automated Detection Engine"
        date = "2026-09-24"
        description = "YARA Signature for "
    strings:
        $str = "Thermo Fisher Applied Biosyste" ascii wide
    condition:
        any of them
}

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⚡ Empfohlene Sofortmaßnahmen

1. Perimeter-Inspektion: Relevante Portfreigaben und exponierte Endpunkte unverzüglich scannen.
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Format: python

#!/usr/bin/env python3
# Exploit Title: PoC for Target
import socket, sys
target = '192[.]168[.]1[.]10'
url = 'hxxp://target[.]local/vuln'
s = socket.socket()
s.connect((target, 80))
s.send(b'GET / HTTP/1.1\r\nHost: target.local\r\n\r\n')

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Thermo Fisher Applied Biosystems Genetic Analyzers

Summary

Background

Vulnerabilities

CVE-2026-17583

Affected Products

Thermo Fisher Applied Biosystems Genetic Analyzers

Remediations

Metrics

Acknowledgments

Legal Notice and Terms of Use

Recommended Practices

Revision History

Legal Notice and Terms of Use

SOC Incident Playbook: Remote Code Execution (RCE) Defense

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Thermo Fisher Applied Biosystems Genetic Analyzers

Summary

Background

Vulnerabilities

CVE-2026-17583

Affected Products

Thermo Fisher Applied Biosystems Genetic Analyzers

Remediations

Metrics

Acknowledgments

Legal Notice and Terms of Use

Recommended Practices

Revision History

Legal Notice and Terms of Use

SOC Incident Playbook: Remote Code Execution (RCE) Defense

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